VEGFA and nonpapillary renal cell carcinoma: The relationship between baseline plasma levels of VEGF and sorafenib benefit was assessed in a phase III multicenter, randomized, double-blind, placebo-controlled study of treatment with sorafenib in 712 ccRCC patients with unresectable and/or metastatic tumor who experienced treatment failure with one prior systemic therapy (Treatment Approaches in Renal Cancer Global Evaluation Trial, TARGET).