mRNA expression of anti-inflammatory genes, such as mannose receptor c-type 1 (CD206), was downregulated in HFD-induced pre-DM mice after 2 weeks, compared with that in control mice at the respective weeks (Figure 5D), whereas inflammatory zone 1 (Fizz1) and c-type lectin domain containing 10, member A (Clec10a) was downregulated after 4 weeks, compared with that in control mice at the respective weeks (Figure 5E,F). Here, CLEC10A is linked to diabetes mellitus.