COX5B and neoplasm: As shown in Table 1, COX5B expression (p = 0.003), gender (p = 0.003), height (p = 0.013), tumor differentiation status (p = 0.029), local invasion grade (p = 0.025), tumor size (p = 0.006), circulating carcinoembryonic antigen (CEA) level (p < 0.001), OCR T/N ratio (p < 0.001), and extracellular acidification rate (ECAR) T/N ratio (p = 0.010) were associated with OS in univariate analysis.