CD69+CD8+ T cells were notably increased in DILI patients compared to NAFLD patients (for F ≤ 1 group: 4.5 ± 1.3 vs. 1.3 ± 0.3, p = 0.006; and for F ≥ 2 group: 4.5 ± 1.3 vs. 2.1 ± 0.3, p = 0.032) and healthy controls (4.5 ± 1.3. Here, CD69 is linked to metabolic dysfunction-associated steatotic liver disease.