TNF and chronic myelogenous leukemia, BCR-ABL1 positive: To evaluate the anti-inflammatory effect of astaxanthin on autoinflammation (Figure 3A), we analyzed the basal mRNA expression of TNFα, IL-1β, IL-6, iNOS, NFATc1, c-Fos, and RAGE without CML-HSA stimulation (Figure 3B–H).