CML-HSA at concentrations of 0.5–2.0 μg/mL was reported to prompt TNFα secretion in an in vitro culture of RAW 264.7 cells, where TNFα secretion reached its highest level after 3 h of CML-HSA treatment and then declined [40], providing evidence for the involvement of TNFα secretion in inflammatory responses. This evidence concerns the gene TNF and chronic myelogenous leukemia, BCR-ABL1 positive.