Nonetheless, although evidence for PD-L1 overexpression in LUAD tumours ultimately remains inconclusive, accumulatively, the discussed data may suggest that PD-L1 expression of tumours with an overexpression of mutant forms of the EGFR might not necessarily be the critical driving force causing the observed resistance to anti-PD-1/PD-L1 treatments. This evidence concerns the gene CD274 and neoplasm.