As the absence of tumour infiltrating lymphocytes (TILs), like the cytotoxic CD8 T-cells, is a well-established marker for poor anti-tumour immune responses following ICI treatments [3], these findings suggested that a lack of CD8 T-cells within mutated EGFR overexpressing tumours may explain why such types of tumours showed only poor responses to ICI treatments. This evidence concerns the gene CD8A and neoplasm.