SPP1 and metabolic dysfunction-associated steatohepatitis: Remmerie et al. showed that in a NASH murine model fed a MCD, two distinct types could be identified among the recruited macrophages: (i) macrophages which resembled KCs in their genetic expression; and (ii) macrophages similar to adipose tissue-derived macrophages, which expressed inflammatory cytokines and osteopontin [126], a recently proposed biomarker of NASH in patients’ serum [128].