However, in stark contrast, miR-210 increases cell proliferation in human osteosarcoma cell lines by modulating the Akt-mTOR signaling pathway by directly silencing PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5) expression through directly targeting the PIK3R5 3′UTR [127]. Here, PIK3R5 is linked to osteosarcoma.