This lack of consensus pertaining to the functional effect of miR-210 in the regulation of H-R-induced apoptotic cell death is further compounded by preponderance of observations emanating from oncological studies that have ascribed a pleiotropic, but diametrically heterogenous, functional profile of augmented miR-210 expression in the tumor-orchestrated hypoxia microenvironment [29,35]. This evidence concerns the gene HR and neoplasm.