Significant cognitive deficits persisted in Shh-inhibited fish out to 7 dpi relative to undamaged fish (sTBI/CYC 1 dpi: 82 ± trials, p < 0.01, 3 dpi: 80 ± trials, p < 0.01, 5 dpi: 67 ± trials, p < 0.01, 7 dpi: 59 ± trials, p < 0.01) before returning to near undamaged levels at 14 dpi (sTBI/CYC 14 dpi: 16 ± trials, p = 0.98). The gene discussed is SHH; the disease is Cognitive impairment.