HMGB1 and COVID-19: In this sense, we have analyzed the clinical trials registered to treat COVID-19 by employing drugs that target some step of NETs release and formation, for example, neutrophil activation (colchicine), NETs release (fostamatinib), DNA degradation (dornase alfa), NE (alvelestat), gasdermin D (disulfiram), HMGB1 (metformin), and ROS (cholecalciferol, N-acetylcysteine and vitamin D).