There was also significant upregulation of FLT1, AKT, ERK1, ERK2, LCN2, COL1A1, TUBB, and VCL in the AD and MCS populations; increased FLK1, FN1, and COL4A5 expression in the MCS population, and increased LAMB2, CDH1, RAF1, MEK1, SRC1, and MTOR expression in the AD population. The gene discussed is COL4A5; the disease is Alzheimer disease.