These data reveal that UC patients with simultaneously high CD276 and TIM-3 expression in tumor have significantly reduced overall survival at the highest risk (hazard ratio = 3.8), which was verified by regression model in dataset GSE13507 and GSE31684, showing 0.69 and 0.97 accuracy rates, respectively, to predict the mortality of these datasets. This evidence concerns the gene HAVCR2 and neoplasm.