Data analysis revealed the presence in the proband of two likely pathogenic variants in the TMPRSS3 gene, known for being causative of autosomal recessive deafness (MIM#: 601072, ORPHA: 90636), together with a likely pathogenic variant in MYH14, a gene described for causing autosomal dominant HL (MIM#: 600652, ORPHA: 90635) (Supplementary Figure S1I,J Table S1). Here, TMPRSS3 is linked to hearing loss, autosomal recessive.