Our multi-step approach led to the identification of a homozygous deletion in the STRC gene in the proband, explaining the HL phenotype, while WES pointed out a nonsense variant, i.e., c.1159C > T, p.(Gln387*), in FLNA gene (NM_001456.3) (Table 1), a gene causative of periventricular nodular heterotopia in an X-linked dominant fashion (MIM#: 300049, ORPHA: 98892) [26]. This evidence concerns the gene STRC and periventricular nodular heterotopia.