Inhibition of the miR-21 expression alleviated steatosis by upregulation of the key regulators of lipid metabolism, such as hepatocyte nuclear factor 4 alpha (Hnf4a), forkhead box transcription factors (Foxa2 and Foxo1), Ppara, and the signal transducer and activator of transcription 3 (Stat3) [134,135]. The gene discussed is STAT3; the disease is steatosis.