Although the expression of ALDH1A3 is not restricted solely to GSCs, the composite ALDH1A3+/ALDH1A1-phenotype is a characteristic trait of GSCs whereas the concomitant expression of both ALDH1A3 and ALDH1A1 isoforms appears to be associated with glioma cells lacking stemness. Here, ALDH1A3 is linked to glioma.