For example, 6,8-diprenylorobol indicated an anticancer effect that induced apoptosis in hepatocellular carcinoma cell lines by inhibiting cytochrome P450 family 2 subfamily J member 2 (CYP2J2) and activating forkhead box O3 (FOXO3) [16]. The gene discussed is FOXO3; the disease is hepatocellular carcinoma.