Thus, we examined the effects of 6,8-diprenylorobol on endometriosis for the following: (1) suppression of cellular proliferation; (2) induction of cell cycle arrest; (3) impairment of mitochondrial function and calcium homeostasis; (4) dysregulation of the intracellular signaling pathway (PI3K/AKT signal); and (5) changes in PI3K/AKT protein expression by 6,8-diprenylorobol with inhibitor. Here, AKT1 is linked to endometriosis.