TRAF3 and neoplasm: The HPV-positive tumors are distinctively characterized by frequent loss of TNF receptor-associated factor 3 (TRAF3) and amplification of E2F transcription factor 1 (E2F1), while HPV-negative tumors often present CDKN2A and TP53 alterations; focal deletions in other tumor suppressor genes (such as NSD1, FAT1, NOTCH1, and SMAD4); and frequent focal amplification of the genes encoding the EGFR, HER2, and FGFR1 receptor tyrosine kinases [104].