VEGFA and neoplasm: Another interesting therapeutic and prognostic target is the VEGF pathway (a member of the platelet-derived growth factor, PDGF, superfamily) [128,129,130,131,132,133,134,135], whose receptors are expressed both on endothelial cells and tumor cells and that include VEGF from A to E. VEGF (mainly VEGF-A) is often overexpressed in HNC and plays a key role as a mediator of angiogenesis, which supports tumorigenesis potentially modulating the tumor microenvironment [136,137].