Treatment possibilities include tumor resection (primary and/or secondary tumor), radical neck dissection, immunotherapy, radiotherapy, checkpoint inhibitors (mainly targeting the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)), programmed cell death protein 1 (PD-1), programmed death-ligand 1 (PD-L1), and chemotherapy [40,41,42,43,44,45]. Here, CD274 is linked to neoplasm.