Following AngII50 treatment there were no signs of cardiac hypertrophy; however, using the slow pressor dose (AngII400), hypertrophy was evident as increased heart weight and increased cardiac mRNA expression of the gene encoding for the hypertrophic markers natriuretic peptide A(nppa) and natriuretic peptide B (nppb) (Table 1). Here, NPPB is linked to cardiac hypertrophy.