It was shown in different mouse models that in the presence of an oncogenic KRAS mutation, ADM is irreversible and leads to the development of pancreatic intraepithelial neoplasia (PanIN), which can further develop into pancreatic ductal adenocarcinoma (PDAC) [4,5,12,27]. The gene discussed is KRAS; the disease is pancreatic ductal adenocarcinoma.