In this context, in situations where there are defects in the inhibition or suppression of the NF-kB pathway, the inflammatory cascade can exacerbate the underlying inflammation from the increased expression of pro-inflammatory cytokines, intensifying insulin resistance, with subsequent hyperglycemia and, with this, acting in the development of GDM, which can also cause the occurrence of maternal and perinatal outcomes [3,72,92]. This evidence concerns the gene NFKB1 and gestational diabetes.