Although the precise mechanism for the role of extracellular Prdx2 in the pathogenesis of brain hemorrhage has not been elucidated, the activation of TLR4 by extracellular Prdx1 has also been reported to be involved in the neuroinflammation that occurs during intracerebral hemorrhagic injury [85]. The gene discussed is PRDX2; the disease is intracranial hemorrhage.