NLRP3 and Parkinson disease: Furthermore, this work showed that antibodies directed against misfolded proteins such as α-Syn and Aβ actually increase NLRP3 activation, contributing to neuroinflammation [28]; despite this, these antibodies are being used in human clinical trials for AD and PD, and, in a contentious decision, one such antibody therapy was recently approved by the FDA for the treatment of mild AD.