MAPT and Alzheimer disease: Interesting, recent evidence suggests that while one or a few misfolded proteins may predominate in a given disease (e.g., Aβ and Tau in AD), other misfolded proteins that are usually associated with another disease (e.g., α-Syn in PD and Lewy body dementia [LBD]) can also be present; for example, more than half of human AD brains have been found to contain misfolded α-Syn, and PD/LBD brains contain Aβ and Tau in addition to predominant α-Syn (for references, see [28]).