LRRK2 and Parkinson disease: De Rose et al. also found that a methanolic extract of W. somnifera root (1%) improved locomotion in male flies in a D. melanogaster leucine-rich repeat kinase 2 (LRRK2) model of Parkinson’s Disease when the flies were aged 3–6 days or 10–15 days but not in flies aged 20–25 days [52].