INS and Nephropathy: We concluded that the HFD + Pol mice exhibited a dysregulation in glucose and insulin metabolism and signs of kidney damage due to their increased levels of MDA, which suggested higher oxidative stress (Figure 4), as well as the results of their gene-expression analyses (Figure 5), where the changes observed in HFD + Pol mice was related to CKD and obesity [52,53,54,55,56], and liver fibrosis.