BAP1 and neoplasm: To examine whether BAP1 might behave as a tumor suppressor of LUAD, we retrieved the RNA-seq data of LUAD and normal lung tissues in humans from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) projects, respectively, and revealed that the levels of Bap1 mRNA expression were significantly higher in normal samples than in LUAD patients (Figure 5C).