HMOX1 and gastrointestinal disease: Moreover, resveratrol increased the activity of heme oxygenase-1 (HO-1), an antioxidant enzyme with therapeutic target against oxidative stress and gastrointestinal diseases, and Nrf2, a transcriptional regulator of HO-1, and in turn, a cellular sensor of oxidative stress and it induces expression of cytoprotective genes, reducing the damage of ROS.