The Keap1-Nrf2 pathway is involved in pancreatic cancer chemoresistance by regulating the expression of drug resistance-associated genes (MRP1, MRP2, MRP3, MRP4, MRP5, and ABCG2) [68,82,83] and previously mentioned cytoprotective antioxidant genes. This evidence concerns the gene KEAP1 and familial pancreatic carcinoma.