Moreover, Duong et al. observed that upregulation of aldehyde dehydrogenase 1 family, member A1 (ALDH1A1) and aldehyde dehydrogenase 3 family, member A1 (ALDH3A1) caused by Nrf2 may also contribute to drug resistance in pancreatic cancers [84]. Here, ALDH3A1 is linked to familial pancreatic carcinoma.