NFKB1 and familial pancreatic carcinoma: Xiang et al. showed that BR inhibits growth and induces apoptosis in pancreatic cancer cells-PATU-8988 and Panc1, through the activation of the JNK (c-Jun N-terminal Kinase)/p38 MAPK (mitogen-activated protein kinase) and subsequent inhibition of NF-κB/STAT3/BCL2 signaling [89].