SQSTM1 and neoplasm: During the early stage of pancreatic carcinogenesis, Nrf2 exerts a tumor-suppressive role by binding to antioxidant response elements and activating its downstream target genes (such as NQO1, SOD1, HO-1, ATF3, IL-17D, and SQSTM1/p62) that regulate the cellular antioxidant/detoxification response, immune surveillance, and autophagy [65,66,67,68].