The Keap1-Nrf2 pathway is involved in pancreatic cancer chemoresistance by regulating the expression of drug resistance-associated genes (MRP1, MRP2, MRP3, MRP4, MRP5, and ABCG2) [68,82,83] and previously mentioned cytoprotective antioxidant genes. Here, NFE2L2 is linked to familial pancreatic carcinoma.