NFE2L2 and metabolic dysfunction-associated steatotic liver disease: Because miR-34a-5p was one of the top 10 upregulated genes in our miRNA microarray validation and because a previous study elucidated the protective role of NRF2 for NAFLD [28], we determined whether miR-34a-5p mediated cellular lipid accumulation by targeting NFE2L2 in high-glucose (HG) + O/P-treated HepG2 cells.