NFE2L2 and fatty liver disease: However, NRF2(L)-KO mice with liver-specific NRF2 knockout on an HFD showed less liver enlargement, inflammation, and hepatic steatosis compared to the wild-type mice; NRF2 (MHFD macrophage-specific NRF2-knockout) mice on an HFD were comparable to the wild-type mice in this regard and showed no significant differences in these parameters [94].