CYP2E1 and fatty liver disease: This increase has been linked with an increased expression of isoform 2E1 of cytochrome P450 (CYP), as valproic acid-induced ROS accumulation and hepatic steatosis were attenuated when CYP2E1 was inhibited using the CYP2E1 inhibitor or CYP2E1 CRISPR knockdown (CYP2E1-KD) [53].