Aggregated TDP-43 in the cytoplasm has been detected in many neurodegenerative diseases, including Alzheimer’s disease (AD) [6], frontotemporal dementia (FTLD) [7,8], limbic-predominant age-related TDP-43 encephalopathy (LATE) [9], and amyotrophic lateral sclerosis (ALS) [10,11,12]. Here, TARDBP is linked to amyotrophic lateral sclerosis.