A detailed biochemical analysis unraveled that ATF3-dependent expression of pro-angiogenic genes, including ANGPT1, Notch1, CX3CL1, KDR (VEGFR2), but not the anti-angiogenic genes, such as TNFα, CXCL9, CXCL10, CXCL11, CXCL14, is responsible for the migration of the tumor cells from the primary sites. Here, KDR is linked to neoplasm.