Furthermore, the latest ChIP-seq data also linked Nrf2 to the expression of genes in angiogenesis (e.g., ANGPT1, VEGFC, CCL2), maintenance of the stem cells or cancer stem cells (PRDM16, TULP4, RUNX, CTNNB1, ULK4, etc.), antagonization of the p53 signals (MDM2, TP63, etc.), and genes that regulate methylation of the DNA and histone proteins. Here, MDM2 is linked to cancer.