Similarly, LOX and LOX-like isoforms have been shown to be transiently increased after injury in a mouse model of permanent ligature of the LAD [33], in which LOX blockade by either the non-selective LOX inhibitor β-aminopropionitrile or a selective LOX neutralizing antibody attenuated collagen accumulation and maturation with a concomitant reduction in ventricular dilatation and an improvement of cardiac function [33]. Here, LOX is linked to Ventriculomegaly.