NOS2 and Parkinson disease: In Parkinson’s disease (PD) genesis, activation of glial cells and enzymes such as reduced nicotinamide adenine dinucleotide phosphate oxidase, inducible nitric oxide synthase, and astrocytic myeloperoxidase, as well as inflammatory factors, such as tumor necrosis factor α and cyclooxygenase-2 play an important role [65].