Given prostaglandin-endoperoxide synthase 2 (PTGS2) is a key modulator of PGF2α synthesis, the bioinformatics analysis showed that lung cancer tissues carried a lower expression of PTGS2 than peritumoural tissues (Figure 4G,H; https://ccsm.uth.edu/miRactDB (accessed on 16 November 2020)). Here, PTGS2 is linked to lung cancer.