Cis-9, trans-11 CLA also improved duodenal redox status by activating Nrf2 to mediate its defense against gliadin-induced enteropathy in mice [22] and had a cytoprotective ability in mouse dendritic cells under LPS or gliadin challenge through the Nrf2 signaling pathway [23]. This evidence concerns the gene NFE2L2 and Abnormal intestine morphology.