SOD1 and amyotrophic lateral sclerosis: A large body of evidence has shown that redox dysregulation of SOD1 during oxidative stress is largely involved in changing the biochemical and biophysical properties of SOD1 causing its abnormal aggregation and misfolding [11,12,13,14,15,16], which is evident in the cellular toxicity observed in ALS [17,18,19,20].