Further, they found that redox disbalance caused by stressors like pathological concentration of H2O2 (1–10 mM), causes unusual TDP-43 cross-linking via Cys oxidation and (-S-S-) formation leading to decreased TDP-43 solubility and hence, TDP-43 formation of toxic aggregates, implicated in the pathology of ALS. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.