TARDBP and amyotrophic lateral sclerosis: Cheng Xu and colleagues (2018) [21], explained how the pathological concentration of H2O2 regulates the redox biology of Cys111 and regulates the misfolding and toxicity of SOD1 and TDP-43 associated with ALS and suggested that sulfenic acid modification of wSOD1 play a crucial role in the pathogenesis of sporadic ALS.