LOF mutations in the CDSN gene cause autosomal recessive genodermatosis peeling skin syndrome 1 (PSS1), whose symptoms involve ichthyosiform erythroderma, FTT, increased IgE levels, eosinophilia, asthma, urticaria/angioedema, and food allergy [148]. Here, IGHE is linked to Increased total eosinophil count.