The decrease in Nrf2 translocation observed in the combined model of PD and mild to moderate stress could be attributed to a decrease in Nrf2 expression [24,78,79], to Nrf2 metabolism alterations [80], or to a reduction in translocation by itself [81,82], induced by MPP+/MPTP; but it could also be related to the CORT effect mediated by the interaction between GR and Nrf2, owing to GR signalling blockage of Nrf2-mediated cytoprotection from oxidative distress [83]. This evidence concerns the gene NR3C1 and Parkinson disease.