IGF2 and Parkinson disease: The protective effect of IGF-II found in the cellular oxidative stress model induced by the CORT [12,13] and the PD models [24,27], which is mediated through its specific IGF-IIR, suggests a potential decrease in the mitochondrial-oxidative damage observed in this combined PD experimental model after IGF-II administration, leading to protecting dopaminergic neurons from cell death.