NFKB1 and cancer: This protein regulates proliferative and survival signaling pathways in normal and cancer cells by maintaining ROS thresholds, activating an antioxidant mechanism dependent on FOXO3 and NF-κB, and modulating them through MAPK/ERK, PI3K/Akt, and AMP kinase pathways [100]; some of these pathways have already been mentioned as associated with oncogenes in HNSCC [14].