TARDBP and amyotrophic lateral sclerosis: Recently, cytoplasmic inclusions of the truncated TAR DNA-binding protein 43 (TDP-43), a pathologic hallmark of the motor neuron neurodegenerative disorder amyotrophic lateral sclerosis (ALS) as well as frontotemporal dementia [183,184,185,186], were shown to trigger the accumulation of LDs in primary cortical astrocytes, suggesting altered lipid metabolism in astrocytes with TDP-43 inclusions, which can affect neuronal function in ALS and frontotemporal dementia given that astrocytes and neurons are a tightly coupled metabolic unit [187].