SPAST and hereditary spastic paraplegia: Moreover, ATL1, SPAST, and REEP1 genes (encoding atlastin-1, spastin, and receptor expression-enhancing protein 1, respectively), the mutations of which cause the neurodegenerative disorder autosomal dominant hereditary spastic paraplegia (HSP) in most cases, were linked to LD metabolism in neurons and/or neuroglial cells [188,189].