A study in a model of alloxan-induced diabetic kidney disease (DKD) in rats revealed that rutin in combination with ramipril alleviated renal damage through a reduction in oxidative stress and renal fibrosis; the authors reported reduced TGF- β1 and increased podocin levels in rats treated by the combination in comparison to untreated rats and rats treated with ramipril alone. The gene discussed is NPHS2; the disease is diabetic kidney disease.