TGFB1 and renal fibrosis: In another model of CKD, Astragalus mongholicus in combination with Angelica sinensis reduced renal fibrosis in chronic puromycin aminonucleoside-induced nephrosis by attenuating the expression of TGF-β1 and impeding renal macrophages localization comparable to renin-angiotensin-aldosterone system (RAAS) blockade by enalapril [83].