NFE2L2 and Hyperglycemia: It has been reported that rutin therapy markedly prevented hyperglycemia-induced endothelial barrier dysfunction in endothelial cells of human renal glomeruli exposed to hyperglycemia by inhibiting the signaling pathway of ras homolog gene family, member A/ Rho-associated protein kinase (RhoA/ROCK) by the activation of Nrf2 [221].