NFE2L2 and chronic kidney disease: The main potential therapeutic strategies in the management of CKD include modulation of the nuclear factor B (NF-κB) signaling pathway [8], activation of autophagy, prevention of mitochondrial dysfunction [9], activation of the nuclear factor erythroid 2-related factor 2 (Nrf-2) pathway, and inhibition of the transforming growth factor β (TGF-β) signaling pathway [10].