Additionally, in another study, ursolic acid impeded the progression of tubulointerstitial fibrosis through attenuating epithelial to mesenchymal transition in renal tubular epithelial cells along with a reduction in markers of fibrosis such as collagen 1, FN, α-SMA, and increase in E-cadherin in a UUO mouse model of CKD. The gene discussed is ACTA1; the disease is chronic kidney disease.