SOD1 and amyotrophic lateral sclerosis: The Nef2l2/NRF2 transcript and protein levels were reduced in NSC-34 (neuron-like) cells transfected with G93A or G37R, mutated SOD1, with the coordinated downregulation of putative NRF2 targets including G6pdx, Prdx3, and Prdx4 [309], suggesting that ALS-associated mutations lead to a downregulation of NRF2-ARE regulon expression.