NFE2L2 and Parkinson disease: In a recent review, it was proposed that boosting NRF2/WNT transcriptional pathways in astrocytes, and enhancing astrocyte-neuron crosstalk pathways, may lead to DAergic neuroprotection [205]; the overexpression of Nfe2l2 was found to rescue DAergic cell loss in both 6-OHDA [193] and MPTP models of PD [192].