NFE2L2 and neuroblastoma: For example, while Yang et al. [342] reported that the triterpenoid CDDO-MA can induce nuclear translocation of NRF2 in neuroblastoma cells and its actions are blocked in NRF2-null fibroblasts, when the efficacy of the triterpenoid CDDO-MA was tested in a mouse model for MPTP-induced DAergic degeneration, the authors did not test whether treatment with the compound increased NRF2 nuclear localization or ARE-containing gene expression in the brain.