NFE2L2 and Parkinson disease: While some studies have documented neuronal NRF2 nuclear translocation (e.g., in DAergic neurons in PD post-mortem tissue [184]), the majority of studies suggest that NRF2 expression is enriched in non-neuronal cells such as astrocytes, microglia, macrophages, and endothelial cells (Figure 2b and Figure 3).