Even though a lack of NRF2 in the context of obesity leads to increased transcription of gluconeogenic genes [45,46] and activation of NRF2 leads to their repression [14,15], gluconeogenic gene expression was not significantly affected by the absence of NRF2 after short- and long-term dexamethasone treatment (Figure 3 and Figure 7). Here, NFE2L2 is linked to obesity due to melanocortin 4 receptor deficiency.