MALAT1 and Taurine upregulated gene 1 (TUG1), which are upregulated in various tumours including HCC, colorectal cancer (CRC), breast cancer, glioblastoma, and hepatocellular carcinoma promote angiogenesis by increasing VEGF expression through sponging miRNAs. The gene discussed is TUG1; the disease is colorectal carcinoma.