In the last year, other new advances in this topic have been published, including the positive effects of LRP5 (HBM mutation or overexpression) in conditions such as hyperglycemia and breast cancer, respectively [464,465], illustrating the relevance of crosstalk between bone and other tissues and the importance of studying the Wnt pathway at a physiological level beyond bone. Here, LRP5 is linked to Hyperglycemia.