Mutations in WNT10A are associated with ectodermal dysplasias, such as odonto-onycho-dermal dysplasia [277], as well as tooth agenesis due to the important role of WNT10A in odontoblast differentiation [78,278,279] (Table 1 and Figure 3). The gene discussed is WNT10A; the disease is ectodermal dysplasia syndrome.