WNT10B and Osteopenia: Interestingly, Wnt10b-KO animals showed an enhanced trabecular structure at 2–4 weeks of age that was rapidly followed by progressive osteopenia, suggesting that Wnt10b helps to maintain osteoblast precursors in an undifferentiated state and that, in its absence, the accelerated differentiation of mesenchymal osteoprogenitors occurs, depleting the stem cell pool [232].