IGF1 and polycystic ovary syndrome: In summary, we found that the combination of Diane-35 and metformin to treat patients with PCOS and EC involved mechanisms that inhibited cell proliferation and ameliorated insulin resistance by repressing the expression of AR, which mediated the onset of cellular autophagy and apoptosis by regulating the PI3K/mTORC pathway through the inhibition of IGF-1.