Herein, in NHL cells, the downregulation of NKILA resulted in an increase in cellular proliferation and decrease in cell death, consistent with the tumor suppressor role of NKILA in multiple tumors, including melanoma, lung cancer, rectal cancer, laryngeal cancer and breast cancer [19,22,36,37,38,39,40]. Here, NKILA is linked to non-Hodgkin lymphoma.