As the constitutive activation of the NF-κB signaling pathway is the hallmark of many lymphoid malignancies, including Hodgkin’s lymphoma and DLBCL [31], and hence implicated in lymphomagenesis, it is essential to comprehend the precise function of NKILA and its interaction with NF-κB in lymphomas. The gene discussed is NFKB1; the disease is lymphoma.