Hemochromatosis excludes the acquired iron overload [1,2], and it is caused by mutations in the five main genes; however, it is more frequently associated with the p.Cys282Tyr (C282Y) homozygous genotype, which is the most common genetic alteration associated with hemochromatosis, in the HFE gene [1,3]. This evidence concerns the gene HFE and hemochromatosis type 1.