HNF4A and Glucose intolerance: Of note, HNF4A regulates the expression of HNF1A [134] and is therefore expected that, with the exception of normoglycemic glycosuria [135], the HNF4A-MODY phenotype is similar to that of HNF1A-MODY, with glucose intolerance becoming evident during adolescence or early adulthood and deteriorating with age [105].